A truck struck and killed a bicyclist about 10:35 a.m. Friday at Bayside Drive and East Coast Highway, a Newport Beach fire official confirmed.
The woman, who was not immediately identified, was in her 20s or 30s, said Battalion Chief Jeff Boyles.
She was riding eastbound on Coast Highway when the stake bed truck ran over her, he said.
The bicyclist was wearing a helmet, said Sgt. Mark Hamilton of the Newport Beach Police Department.
The truck was traveling eastbound on Coast Highway and was making a right turn onto Bayside, Boyles said.
It was unclear whether the cyclist also was making a turn.
The woman was pronounced dead at the scene.