The Sea Kings torched the host Trojans for six touchdowns in the first half en route to a 49-21 blowout win on Thursday night.
No team has been able to knock off CdM in the past nine league contests dating back to last year.
With the league finale next week, the Sea Kings (8-1, 4-0 in league) will most likely have to defend their league title against Beckman.
The top-ranked and second-ranked team in the CIF Southern Section Southern Division will play for the league crown, if Beckman (6-2, 3-0) gets past Irvine Friday.
"We've always hoped that it would," said CdM Coach Scott Meyer, when asked if he wanted it to play out this way, the Sea Kings and Patriots meeting for the league title at Newport Harbor High. "We expected Beckman to be there and we'd hope we would be the other team there to try to play for that league championship."
The Sea Kings expect a dogfight if they plan to claim back-to-back league titles for the first time since they won in 1987 and '88. It won't be easy, especially as it was against University.
The Trojans (3-6, 1-3) challenged Beckman a week ago, losing 24-21 on a last-second field goal. Their latest contest was over in the first quarter.
Forty-nine seconds in, quarterback Brent Lawson broke a CdM regular-season passing record. On a simple swing pass, Lawson threw his 19th touchdown of the year, breaking the record set by Mitch Sands three years ago.
Josh Giger helped Lawson out with an impressive run-after-the-catch effort. The senior did most of the work on the 51-yard touchdown.
Lawson and Giger were just getting started.
Giger scored the Sea Kings' second touchdown. This time, he rushed into the end zone on a seven-yard end-around play. The touchdown on the ground was the first of two by Giger, who recorded his first three-touchdown game.
Giger and Lawson have found a rhythm in the past two weeks, hooking up 14 times for 260 yards and three touchdowns in the air.