The Lions shot 29.5% from the field (18 for 61) and were outrebounded, 34-24.
Seniors Molly Pfohl (15 points and eight rebounds) and Sarah Boyd (12 points and seven assists), led the way for the Lions, who received 10 points and six rebounds from Allison Burns.
Vanguard led by one point twice in the first half, but never got closer than four in the second half.
Langston, from Oklahoma, is 29-5.
COSTA MESA — Rachael Hellyer pitched a six-inning shutout in an 8-0 win over Doane of Nebraska that closed out a nonconference sweep for the host Lions on Thursday.
Vanguard (18-8) won the first game, 5-1, as Kaysle Flasck went two for three with two runs batted in to pace a five-hit attack.
Vanguard had 11 hits in the second game. Elizabeth Archer was three for three with two RBIs, Flasck was two for two and Ariana Atwater had one hit and three RBIs.
Patricia Olvera allowed one run on five hits in six innings to earn the pitching victory in Game 1.
Doane is 1-11.
Orange Coast 8, Fullerton 1
COSTA MESA — The host Pirates swept in doubles and won five of six singles sets in the Orange Empire Conference match Thursday.
Rex Miller, Jesse Chen, Trevor Dalbey and Aaron Lester won in singles and doubles for the Pirates (7-5, 4-2 in conference.
COSTA MESA — Host Vanguard university topped Lewis-Clark State, 5-4, and lost to Midwestern, 8-1, in nonconference matches Thursday at Costa Mesa Tennis Center.
Vanguard is 4-8.
COSTA MESA — Host Vanguard University defeated Lewis-Clark State, 7-2, and lost to Midwestern, 6-3, in nonconference matches Thursday at Costa Mesa Tennis Center.
Vanguard is 6-4.