The play ended with a sack, however, and Mesa fell to 0-3.
The last two times Corona del Mar High began the season at 4-0, it went on to win CIF Southern Section titles.
CdM, ranked No. 7 in the CIF Southern Section Southern Division, has a shot Friday to start the season with four straight victories. In the way is rival Newport Harbor, ranked No. 8 in the Pac-5 Division.
The Sailors are the home team in the Battle of the Bay at 7 p.m.
The Sea Kings' previous two 4-0 starts came in 1989 and 1988, two seasons in which CdM claimed Division IV crowns. Those are the football program's only section championships.
A win against Newport Harbor would be CdM's first against the Sailors since 2006.
Newport Harbor High tailback Buzzy Yokoyama limped off the football field Friday after Loyola of Los Angeles dropped him for a loss for the first time.
Yokoyama went over the 100-yard mark in his previous carry. The seven-yard loss put him beneath the total and he began favoring his left leg with 5:10 left in the first half.
Yokoyama bounced back in a major way.
The junior went on to record 197 of his career-best 294 yards and three touchdowns after the setback, lifting Newport Harbor to a 35-28 nonleague road victory.
Yokoyama said he felt fine after the Sailors improved to 2-0. He looked better than that.
The big games keep coming for Sage Hill School senior running back Taylor Ross, who rushed for 204 yards and two touchdowns Friday night in a 35-24 nonleague victory over Mojave. It was Ross' third straight 200-yard game to open the season.
Ross now has 667 yards through three games. The school record belongs to Keya Manshadi, who had 1,060 yards in 2005.